1. 药材主信息
| 中文名称: | 长春花 |
| 英文名称: | Madagascar Periwinkle |
| 拉丁名称: | Catharanthus roseus |
| 使用部位: | whole herb |
| 功用: | To resolve toxin, clear heat and calm liver, anticancer. |
| 适用症: | Hypertension, swelling toxin of welling abscess and sore, scalds. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 5096-57-1 | (-)-四氢小檗碱 | (S)-Canadine | 21171 |
| 826-36-8 | 四甲基哌啶酮 | 2,2,6,6-Tetramethyl-4-piperidone | 13220 |
| 20072-25-7 | - | 4'-Deoxyvinblastine | 161300 |
| 41547-82-4 | 腺苷 | Adenosine | 60961 |
| 41547-82-4 | 腺苷 | Adenosine | 60961 |
| 483-04-5 | 阿马碱 | Ajmalicine | 441975 |
| 1355-31-3 | - | Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(9S)-3-formyl-5-ethyl-1,2,3,6,7,8,9,10-octahydro-9-(methoxycarbonyl)azacycloundecino[5,4-b]indol-9-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2beta,3beta,4beta,5alpha,12R,19alpha)- | 11953924 |
| 83-46-5 | β-谷甾醇 | Beta-Sitosterol | 222284 |
| 61231-06-9 | - | Catheduline E2 | 442517 |
| 119188-33-9 | 二羟丙茶碱A | Coronarin A | 24851535 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| BECN1 | ATG6; VPS30; beclin1 | 17q21.31 | 23664889 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 31020375 |
| HMOX1 | HMOX1D; HO-1; HSP32; bK286B10 | 22q12.3 | 31020375 |
| MAPK1 | ERK; ERK-2; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p38; p40; p41; p41mapk; p42-MAPK | 22q11.22 | 27270426 |
| NFE2L2 | HEBP1; IMDDHH; NRF2; Nrf-2 | 2q31.2 | 31020375 |
| NFKB1 | CVID12; EBP-1; KBF1; NF-kB; NF-kB1; NF-kappa-B1; NF-kappaB; NF-kappabeta; NFKB-p105; NFKB-p50; NFkappaB | 4q24 | 31020375 |
| PDGFRA | CD140A; PDGFR-2; PDGFR2 | 4q12 | 30082792 |
| STMN1 | C1orf215; LAP18; Lag; OP18; PP17; PP19; PR22; SMN | 1p36.11 | 30082792 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Alopecia | disease | 22371887 |
| Astrocytoma | disease | 27573663 |
| Brain Neoplasms | group | 27573663 |
| Brain Neoplasms | group | 22393086 |
| Brain Neoplasms | group | 21764821 |
| Carcinoma, Transitional Cell | disease | 31702432 |
| Carcinoma, Transitional Cell | disease | 21502557 |
| Colorectal Neoplasms | group | 23664889 |
| Fatigue | phenotype | 22371887 |
| Fibromatosis | disease | 24212959 |
