科华智慧(深圳)创新药物研发有限公司     西北农林科技大学深圳研究院    联合开发

1. 药材主信息

中文名称: 白附子
英文名称: rhizome of Giant Typhonium
拉丁名称: Rhizoma Typhonii
使用部位: -
功用: To dispel wind-phlegm, to check convulsions, and to counteract toxicity, promote subsidence of modulation and relieve pain.
适用症: Treatment of stroke with gurgling in the throat, deviation of the eye and the mouth, and impairment of speech, upward invasion of phlegm causing headache accompanied with dizziness, heaviness of the body, restlessness, fidgetness, nausea and cold extremit
毒副作用: Toxic

2. 相关成分

CAS号 中文名称 英文名称 参考文献
40856-79-9 - (5s)-5-(4-Hydroxybenzyl)imidazolidine-2,4-dione 233111
829-26-5 - 2,3,6-Trimethylnaphthalene 13237
17241-40-6 2-羟基-3-甲基蒽醌 2-Hydroxy-3-methylanthraquinone 10889963
120-75-2 - 2-Methylbenzothiazole 8446
91-57-6 - 2-Methylnaphthalene 7055
17581-85-0 3-(4-Methoxyphenyl)-2-propen-1-ol 3-(4-Methoxyphenyl)-2-propen-1-ol 5314180
832-71-3 3-甲基菲 3-Methylphenanthrene 13258
83946-90-1 (E)-6-O-对香豆酰鸡屎藤次苷甲酯 6-O-E-pcoumaroyl scandoside methyl ester 44584784
120-12-7 - Anthracene 8418
25368-11-0 车叶草苷酸 Asperulosidic acid 11968867

3. 相关靶点

基因靶点 基因别名 靶点位置 参考文献
ABCB11 ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; SPGP 2q31.1 24107776
ABCC2 ABC30; CMOAT; DJS; MRP2; cMRP 10q24.2 24107776
ABCG5 STSL; STSL2 2p21 24107776
ABCG8 GBD4; STSL; STSL1 2p21 24107776
AKT1 AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA 14q32.33 21168456
AKT1 AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA 14q32.33 21708244
AKT1 AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA 14q32.33 24000005
AKT1 AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA 14q32.33 27472952
APP AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2; preA4 21q21.3 24107941
BACE1 ASP2; BACE; HSPC104 11q23.3 24107941

4. 相关疾病