科华智慧(深圳)创新药物研发有限公司     西北农林科技大学深圳研究院    联合开发

1. 药材主信息

中文名称: 鲜地黄
英文名称: Adhesive Rehmannia Fresh Root
拉丁名称: Rehmannia glutinosa [Syn. Rehmannia glutinosa f. h
使用部位: fresh root
功用: To clear heat and cool blood, engender liquid and moisten dryness, lower blood sugar levels.
适用症: Diabetes mellitus, dermatitis, rheumatism, diphtheria, acute tonsillitis, acute febrile diseases, ardent fever with clouded spirit, macula, fluid damage with vexation and thirst, blood ejection due to blood heat, spontaneous external bleeding due to blood heat, flooding and spotting due to blood heat, hematochezia due to blood heat, mouth and tongue sores, swelling pain in throat, taxation fever cough, painful wound from knocks and falls, swollen welling abscess.
毒副作用: -

2. 相关成分

CAS号 中文名称 英文名称 参考文献
41547-82-4 腺苷 Adenosine 60961
13382-86-0 甘露三糖 Manninotriose 5461026
69-65-8 D-甘露醇 Mannitol 6251
81720-06-1 - Rehmannioside B 101654196

3. 相关靶点

基因靶点 基因别名 靶点位置 参考文献
ABCC2 ABC30; CMOAT; DJS; MRP2; cMRP 10q24.2 31378931
AKT1 AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA 14q32.33 29284152
ATF6 ACHM7; ATF6A 1q23.3 28655643
BAX BCL2L4 19q13.33 23550774
BCL2 Bcl-2; PPP1R50 18q21.33 23550774
DDIT3 AltDDIT3; C/EBPzeta; CEBPZ; CHOP; CHOP-10; CHOP10; GADD153 12q13.3 28655643
GLP1R GLP-1; GLP-1-R; GLP-1R 6p21.2 26546042
HSF1 HSTF1 8q24.3 28655643
HSPA5 BIP; GRP78; HEL-S-89n; MIF2 9q33.3 28655643
KLHL1 MRP2 13q21.33 31378931

4. 相关疾病

疾病名称 疾病类型 参考文献
Colitis disease 28655643
Diabetes Mellitus, Experimental disease 29284152
Insulin Resistance phenotype 29284152