1. 药材主信息
| 中文名称: | 吴芋 |
| 英文名称: | fruit of Diverseflower Evodia |
| 拉丁名称: | Fructus Evodiae |
| 使用部位: | Evodia rutaecarpa (Juss.) Benth.;Evodia rutaecarpa (Juss.) Benth. var. officinalis (Dode) Huang;Evodia rutaecarpa (Juss.) Benth. var. bodinieri (Dode) Huang |
| 功用: | Treatment of headache accompanied by retching and cold limbs, abdominal colic, weakness and edema of the legs, abdominal pain during menstruation, epigastric distension and pain with vomiting and acid regurgitation, diarrhea occurring before dawn daily, hypertension. External use for ulcers in the mouth. |
| 适用症: | 1. Its volatile oil containing evoden inhibits the abnormal fermentation in the intestine.2. Evodin, evodiamine and rutaecarpine, are active components for analgesic.3. Oral administration or injection can lower blood pressure in normal animals or those with renal hypertension. |
| 毒副作用: | Toxic |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 498-15-7 | (1S)-(+)-3-蒈烯 | (+)-3-Carene | 443156 |
| 7785-70-8 | (1R)-(+)-alpha-蒎烯 | (+)-alpha-Pinene | 82227 |
| 21368-68-3 | (±)-樟脑 | Camphor | 2537 |
| 154-23-4 | (+)-儿茶素 | Cianidanol | 9064 |
| 518-17-2 | 吴茱萸碱 | Evodiamine | 442088 |
| 6753-98-6 | α-石竹烯 | Humulene | 5281520 |
| 118-65-0 | (-)-异丁香烯 | Isocaryophyllene | 5281522 |
| 73904-93-5 | Isolimonexic acid | Isolimonexic acid | 5321282 |
| 6730-83-2 | 异贝壳杉烯酸 | Kaurenoic acid | 73062 |
| 1180-71-8 | 柠檬苦素（吴茱萸内酯） | Limonin | 179651 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| IL6 | BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6 | 7p15.3 | 23032719 |
| JAK2 | JTK10; THCYT3 | 9p24.1 | 23032719 |
| MAPK1 | ERK; ERK-2; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p38; p40; p41; p41mapk; p42-MAPK | 22q11.22 | 23032719 |
| MAPK3 | ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A; P44ERK1; P44MAPK; PRKM3; p44-ERK1; p44-MAPK | 16p11.2 | 23032719 |
| SRC | ASV; SRC1; THC6; c-SRC; p60-Src | 20q11.23 | 23032719 |
| STAT3 | ADMIO; ADMIO1; APRF; HIES | 17q21.2 | 23032719 |
| TRPV1 | VR1 | 17p13.2 | 23025809 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Cardiomyopathies | group | 31064352 |
| Coronary Artery Disease | disease | 23025809 |
| Fatty Liver | disease | 23025809 |
| Hyperlipidemia | disease | 23025809 |
| Liver neoplasms | group | 23032719 |
