1. 药材主信息
| 中文名称: | 商陆 |
| 英文名称: | Pokeberry Root |
| 拉丁名称: | Radix Phytolaccae |
| 使用部位: | root |
| 功用: | To cause drastic purgation and also diuresis, to counteract toxicity, and to reduce modulation. |
| 适用症: | Edema distention fullness, urinary and fecal stoppage, swelling toxin of welling abscess and sore. |
| 毒副作用: | Toxic |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 89808-50-4 | 商陆皂苷 D | (2S,4aR,6aR,6aS,6bR,8aR,9R,10R,11S,12aR,14bS)-11-hydroxy-9-(hydroxymethyl)-2-methoxycarbonyl-2,6a,6b,9,12a-pentamethyl-10-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid | 102004522 |
| 56283-68-2 | - | (3I(2),4I+/-,20I(2))-3,23-Dihydroxyolean-12-ene-28,29-dioic acid | 101297621 |
| 50373-29-0 | - | (r)-2-Ethylhexanol | 6991979 |
| 2277-28-3 | - | alpha-Glyceryl linoleate | 6436630 |
| 481-18-5 | α-菠菜甾醇 | alpha-Spinasterin | 5281331 |
| 484-20-8 | 佛手柑内酯 | Bergapten | 2355 |
| 484-20-8 | 佛手柑内酯 | Bergapten | 2355 |
| 372-75-8 | L-瓜氨酸 | Citrulline | 9750 |
| 84-74-2 | 邻苯二甲酸二丁酯（植物提取） | Dibutyl Phthalate | 3026 |
| 140231-40-9 | - | Esculentagenin | 132278 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 26148846 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 27836781 |
| BAX | BCL2L4 | 19q13.33 | 27836781 |
| BECN1 | ATG6; VPS30; beclin1 | 17q21.31 | 26148846 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 27756327 |
| CASP8 | ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5 | 2q33.1 | 27756327 |
| CASP9 | APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56 | 1p36.21 | 27756327 |
| DDIT3 | AltDDIT3; C/EBPzeta; CEBPZ; CHOP; CHOP-10; CHOP10; GADD153 | 12q13.3 | 28780078 |
| DGKD | DGK-delta; DGKdelta; dgkd-2 | 2q37.1 | 28707095 |
| GSK3B | - | 3q13.33 | 27836781 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Diabetes | disease | 28707095 |
| Hyperglycemia | disease | 28707095 |
| Pancreatic Neoplasm | disease | 27756327 |
| Parkinson Disease | disease | 28780078 |
