1. 药材主信息
| 中文名称: | 京大戟 |
| 英文名称: | Peking Euphorbia Root |
| 拉丁名称: | Radix Euphorbiae Pekinensis |
| 使用部位: | - |
| 功用: | To cause drastic purgation. |
| 适用症: | Treatment of anasarca, hydrothorax and ascites with dyspnea, constipation and oliguria. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 24211-30-1 | - | (S)-2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-4-benzopyrone | 442396 |
| 506-51-4 | 二十四烷醇 | 1-Tetracosanol | 10472 |
| 89-86-1 | 2,4-二羟基苯甲酸 | 2,4-Dihydroxybenzoic acid | 1491 |
| 2239-88-5 | 3,3’-O-二甲基鞣花酸 | 3,3'-Di-O-methylellagic acid | 5488919 |
| 28610-31-3 | 8-异戊烯基山柰酚 | 8-Prenylkaempferol | 5318624 |
| 20362-31-6 | 牛蒡子苷 | Arctiin | 100528 |
| 83-46-5 | β-谷甾醇 | Beta-Sitosterol | 222284 |
| 469-38-5 | 环阿屯醇 | Cycloartenol | 92110 |
| 523-94-4 | - | Dambonitol | 21627888 |
| 514-47-6 | 大戟二烯醇 | Euphol | 441678 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 23684930 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 26784390 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 20840540 |
| BAX | BCL2L4 | 19q13.33 | 30326282 |
| BCL2 | Bcl-2; PPP1R50 | 18q21.33 | 30326282 |
| BNIP3 | NIP3 | 10q26.3 | 28838842 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 26418626 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 30326282 |
| CASP8 | ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5 | 2q33.1 | 30326282 |
| CASP9 | APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56 | 1p36.21 | 30326282 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Alzheimer's Disease | disease | 30447302 |
| Colitis | disease | 22677088 |
| Crohn Disease | disease | 22677088 |
| Diabetes | disease | 28707095 |
| Electrocardiography | phenotype | 23058930 |
| Esophageal Neoplasms | group | 26603620 |
| Helicobacter Infections | group | 29566160 |
| Hyperglycemia | disease | 28707095 |
| Hyperlipidemia | disease | 23058930 |
| Hypertrophy | phenotype | 23058930 |
