1. 药材主信息
| 中文名称: | 积雪草 |
| 英文名称: | Asiatic Pennywort Herb |
| 拉丁名称: | herba centellae |
| 使用部位: | whole herb with root |
| 功用: | To remove heat and damp, to counteract toxicity, and to cause subsidence of swelling. |
| 适用症: | Sand qi abdominal pain, summerheat-heat diarrhea, dysentery, damp-heat jaundice, sand strangury, blood strangury, blood ejection, spontaneous external bleeding, red eyes, swollen throat, wind papules, scab and lichen, swelling toxin of clove welling abscess, knocks and falls, hypertension. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 7785-26-4 | (1S)-(-)-α-蒎烯 | (-)-alpha-Pinene | 440968 |
| 14073-97-3 | (-)-薄荷酮 | (-)-Menthone | 26447 |
| 26532-66-1 | - | (1S,2R,4aS,6aR,6aS,6bR,8R,8aR,10R,11R,12aR,14bS)-8,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid | 69569689 |
| 18449-41-7 | - | (4R)-2alpha,3beta,6beta,23-Tetrahydroxyurs-12-en-28-oic acid | 6710742 |
| 19870-46-3 | 1,5-二咖啡酰奎宁酸 | 1,3-Dicaffeoylquinic acid | 6474640 |
| 57378-72-0 | 4,5-二-O-咖啡酰奎宁酸（异绿原酸C） | 3,4-Dicaffeoylquinic acid | 6474309 |
| 56645-88-6 | - | Aloinoside A | 46173997 |
| 11006-91-0 | - | Aloinoside B | 46173998 |
| 1862-41-5 | - | Anonaine | 160597 |
| 520-36-5 | 芹菜素 | Apigenin | 5280443 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| ACACA | ACAC; ACACAD; ACC; ACC1; ACCA | 17q12 | 28358365 |
| ADRB2 | ADRB2R; ADRBR; B2AR; BAR; BETA2AR | 5q32 | 26746354 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 21871133 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 31678208 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 26746354 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 21168456 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 21708244 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 24000005 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 27472952 |
| BAX | BCL2L4 | 19q13.33 | 29228978 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Adenocarcinoma | group | 21550230 |
| Blood Pressure | phenotype | 28143892 |
| Brain Infarction | disease | 22511009 |
| Brain Ischemia | disease | 30414381 |
| Cognition Disorders | group | 21708244 |
| Colitis | disease | 28358365 |
| Colonic Neoplasms | group | 23330808 |
| Colorectal Neoplasms | group | 27472952 |
| Colorectal Neoplasms | group | 22832932 |
| Cystadenocarcinoma, Serous | disease | 29879497 |
