1. 药材主信息
| 中文名称: | 虎耳草 |
| 英文名称: | stem or leaf of Fung Waxplant |
| 拉丁名称: | Herba Saxifragae |
| 使用部位: | whole herb |
| 功用: | For clearing heat and removing toxic substances |
| 适用症: | Wind papules, eczema, otitis media, erysipelas, cough with blood ejection, pulmonary welling abscess, flooding and spotting, hemorrhoids. |
| 毒副作用: | Extremely Toxic |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 79595-97-4 | - | (2S,3R,4R,4aS,10bR)-3,4,8,9,10-pentahydroxy-2-(hydroxymethyl)-3,4,4a,10b-tetrahydro-2H-pyrano[3,2-c]isochromen-6-one | 73192 |
| 99-93-4 | 4'-羟基苯乙酮 | 4'-Hydroxyacetophenone | 7469 |
| 497-76-7 | 熊果苷（β型） | Arbutin | 440936 |
| 6750-30-7 | 山金车二醇、阿里二醇 | Arnidiol | 10478550 |
| 477-90-7 | 岩白菜素 | Bergenin | 66065 |
| 492-14-8 | 紫铆亭 | Butin | 92775 |
| 331-39-5 | 咖啡酸 | Caffeic Acid | 689043 |
| 327-97-9 | 绿原酸 | Chlorogenic Acid | 1794427 |
| 62-49-7 | 2-羟基-N,N,N-三甲基乙铵 | Choline | 305 |
| 154-23-4 | (+)-儿茶素 | Cianidanol | 9064 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 20840540 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 27017346 |
| BAX | BCL2L4 | 19q13.33 | 30326282 |
| BCL2 | Bcl-2; PPP1R50 | 18q21.33 | 30326282 |
| BCL2L1 | BCL-XL/S; BCL2L; BCLX; Bcl-X; PPP1R52 | 20q11.21 | 29247826 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 27756327 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 30326282 |
| CASP8 | ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5 | 2q33.1 | 27756327 |
| CASP8 | ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5 | 2q33.1 | 30326282 |
| CASP9 | APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56 | 1p36.21 | 27756327 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Aging | phenotype | 24932939 |
| Alzheimer's Disease | disease | 31560162 |
| Alzheimer's Disease | disease | 30447302 |
| Atherosclerosis | disease | 27017346 |
| Down Syndrome | disease | 24932939 |
| Esophageal Neoplasms | group | 26603620 |
| Ischemia | phenotype | 27017346 |
| Lung Neoplasms | group | 29988033 |
| Lung Neoplasms | group | 29247826 |
| Melanoma, Experimental | disease | 20840540 |
