1. 药材主信息
| 中文名称: | 甘草 |
| 英文名称: | Root of Ural Licorice |
| 拉丁名称: | Radix Glycyrrhizae |
| 使用部位: | root and rhizome |
| 功用: | To reinforce the function of the spleen and replenish qi, to remove heat and counteract toxicity, to dispel phlegm and relieve cough, to alleviate spasmodic pain, and to moderate drug actions. |
| 适用症: | 1. Its decoction can inhibit intestinal smooth muscles of rabbins in vitro, but glycyrrhizin and glycyrrhetinic acid have no this effect.2. Possessing an adrenocorticomimetic effect.3. Its extract and glycyrrhizin exerts a detoxifying effect.4. Antitussive and antiasthmatic. 5. Glycyrrhizin has anti-inflammatory effect similar to hydrocortisone. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 506-30-9 | 花生酸 | - | 10467 |
| 15356-60-2 | D-薄荷醇 | (+)-Menthol | 165675 |
| 20549-46-6 | - | (+)-Neoisopulegol | 6553885 |
| 480-41-1 | - | (2R)-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one | 667495 |
| 118525-49-8 | - | (2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,14a-dodecahydropicen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid | 452864 |
| 118525-49-8 | - | (2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,14a-dodecahydropicen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid | 452864 |
| 87686-86-0 | 6-羟基甲基异茜草素 | 1,3,6-Trihydroxy-2-methylanthracene-9,10-dione | 5319801 |
| 71-36-3 | - | 1-Butanol | 263 |
| 129280-35-9 | - | 1-Methoxyficifolinol | 480872 |
| 65428-13-9 | 1-甲氧基菜豆素 | 1-Methoxyphaseollidin | 480873 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| ABCC2 | ABC30; CMOAT; DJS; MRP2; cMRP | 10q24.2 | 21445586 |
| AGER | RAGE; SCARJ1 | 6p21.32 | 22989295 |
| AGER | RAGE; SCARJ1 | 6p21.32 | 31035509 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 29096683 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 31174572 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 31438982 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 27710830 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 29807112 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 20840540 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 21168456 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Asthma | disease | 31226782 |
| Blood Pressure | phenotype | 25076013 |
| Cerebral Hemorrhage | phenotype | 28610608 |
| Chemical and Drug Induced Liver Injury | disease | 30024038 |
| Chronic liver disease | group | 21354229 |
| Cognition Disorders | group | 21708244 |
| Colitis | disease | 25281414 |
| Colonic Neoplasms | group | 23330808 |
| Colorectal Neoplasms | group | 27710830 |
| Colorectal Neoplasms | group | 23824743 |
