1. 药材主信息
| 中文名称: | 大蓟 |
| 英文名称: | Peking Euphorbia |
| 拉丁名称: | Euphorbia pekinensis |
| 使用部位: | tuberoid |
| 功用: | To drain water and expel rheum, dissipate binds and disperse swelling. |
| 适用症: | Edema, seeper in chest and abdomen, phlegm-rheum, inhibited urine and stool, swollen welling abscess, scrofula. |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 2239-88-5 | 3,3’-O-二甲基鞣花酸 | 3,3'-Di-O-methylellagic acid | 5488919 |
| 469-38-5 | 环阿屯醇 | Cycloartenol | 92110 |
| 149-91-7 | 没食子酸 | Gallic Acid | 370 |
| 486-21-5 | 异嗪皮啶 | Isofraxidin | 5318565 |
| 99-24-1 | 没食子酸甲酯 | Methyl gallate | 7428 |
| 121521-90-2 | 丹酚酸B | Salvianolic acid B | 6451084 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 23684930 |
| BNIP3 | NIP3 | 10q26.3 | 28838842 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 26418626 |
| CYCS | CYC; HCS; THC4 | 7p15.3 | 26418626 |
| CYP2J2 | CPJ2; CYPIIJ2 | 1p32.1 | 24216999 |
| CYP4F2 | CPF2 | 19p13.12 | 24216999 |
| EPHX2 | ABHD20; CEH; SEH | 8p21.2-p21.1 | 24216999 |
| HMOX1 | HMOX1D; HO-1; HSP32; bK286B10 | 22q12.3 | 24216999 |
| HMOX2 | HO-2 | 16p13.3 | 24216999 |
| ICAM1 | BB2; CD54; P3.58 | 19p13.2 | 31981623 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Alzheimer's Disease | disease | 30447302 |
| Colitis | disease | 22677088 |
| Crohn Disease | disease | 22677088 |
| Electrocardiography | phenotype | 23058930 |
| Helicobacter Infections | group | 29566160 |
| Hyperlipidemia | disease | 23058930 |
| Hypertrophy | phenotype | 23058930 |
| Mitochondrial Swelling | phenotype | 26418626 |
| Myocardial Infarction | disease | 23058930 |
| Necrosis | phenotype | 28838842 |
