1. 药材主信息
| 中文名称: | 大蓟 |
| 英文名称: | Peking spurge root |
| 拉丁名称: | Radix euphorbiae pekinensis |
| 使用部位: | Euphorbia pekinesis Rupr.;Knoxia valerianoides Thorel et Pitard |
| 功用: | 1. Treatment of edema of the face and the body, retention of fluid in the chest and ascites. Peking spurge root (Daji) is used with Jujube (Dazao), Kansui root (Gansui) and Genkwa flower (Yuanhua) in the formula Shizao Tang. 2. Treatment of boils, carbuncles, scrofula and subcutaneous nodules. Peking spurge root (Daji) is used with Pleione rhizome (Shancigu) and Moleplant seed (Qianjinzi) for internal and external use in the formula Zijin Ding. |
| 适用症: | 1. Treatment of edema of the face and the body, retention of fluid in the chest and ascites. Peking spurge root (Daji) is used with Jujube (Dazao), Kansui root (Gansui) and Genkwa flower (Yuanhua) in the formula Shizao Tang. 2. Treatment of boils, carbunc |
| 毒副作用: | - |
2. 相关成分
| CAS号 | 中文名称 | 英文名称 | 参考文献 |
| 2239-88-5 | 3,3’-O-二甲基鞣花酸 | 3,3'-Di-O-methylellagic acid | 5488919 |
| 469-38-5 | 环阿屯醇 | Cycloartenol | 92110 |
| 149-91-7 | 没食子酸 | Gallic Acid | 370 |
| 99-24-1 | 没食子酸甲酯 | Methyl gallate | 7428 |
| 121521-90-2 | 丹酚酸B | Salvianolic acid B | 6451084 |
3. 相关靶点
| 基因靶点 | 基因别名 | 靶点位置 | 参考文献 |
| AKT1 | AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA | 14q32.33 | 23684930 |
| BNIP3 | NIP3 | 10q26.3 | 28838842 |
| CASP3 | CPP32; CPP32B; SCA-1 | 4q35.1 | 26418626 |
| CYCS | CYC; HCS; THC4 | 7p15.3 | 26418626 |
| CYP2J2 | CPJ2; CYPIIJ2 | 1p32.1 | 24216999 |
| CYP4F2 | CPF2 | 19p13.12 | 24216999 |
| EPHX2 | ABHD20; CEH; SEH | 8p21.2-p21.1 | 24216999 |
| HMOX1 | HMOX1D; HO-1; HSP32; bK286B10 | 22q12.3 | 24216999 |
| HMOX2 | HO-2 | 16p13.3 | 24216999 |
| ICAM1 | BB2; CD54; P3.58 | 19p13.2 | 31981623 |
4. 相关疾病
| 疾病名称 | 疾病类型 | 参考文献 |
| Alzheimer's Disease | disease | 30447302 |
| Colitis | disease | 22677088 |
| Crohn Disease | disease | 22677088 |
| Electrocardiography | phenotype | 23058930 |
| Helicobacter Infections | group | 29566160 |
| Hyperlipidemia | disease | 23058930 |
| Hypertrophy | phenotype | 23058930 |
| Mitochondrial Swelling | phenotype | 26418626 |
| Myocardial Infarction | disease | 23058930 |
| Necrosis | phenotype | 28838842 |
